Publication date 2003 - Basic Science
Buma P, de Groot JH, Heijkants RG, Pennings AJ., Tienen TG, Veth RP

A porous polymer scaffold for meniscal lesion repair–a study in dogs.

Meniscal lesions often occur in the avascular area of the meniscus with little chance of spontaneous repair. An access channel in the meniscal tissue can function as an entrance for ingrowing repair tissue from the vascular periphery of the meniscus to the lesion in the avascular zone which again induced healing of the lesion. Implantation of a porous polymer in a full-thickness access channel induced healing. However, a better integration between meniscal tissue and the implant might be achieved with the combination of the newly developed porous polymers and a modified surgical technique. This might improve meniscal lesion healing and the repair of the access channel with neo-meniscal tissue.

Longitudinal lesions were created in the avascular part of 24 canine lateral menisci and a partial-thickness access channel was formed to connect the lesion with the meniscal periphery. In 12 menisci, the access channel was left empty (control group), while in the remaining 12 menisci the polymer implant was sutured into the access channel.

Repair of the longitudinal lesions was achieved with and without polymer implantation in the partial-thickness access channel. Polymer implants induced fibrous ingrowth with cartilaginous areas, which resembled neo-meniscal tissue. Implantation did not prevent articular cartilage degeneration.

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2021 - Clinical Study

A comparison between Polyurethane and Collagen Meniscal Scaffold for Partial Meniscal Defects: Similar positive clinical results at a mean of 10-Years of Follow-up.

Filardo G, Grassi A, Lucidi GA, Poggi A, Reale D, Zaffagnini S
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2011 - Basic Science

A pre-clinical test platform for the functional evaluation of scaffolds for musculoskeletal defects: the meniscus.

Bonassar LJ, Maher SA., Potter HG, Rodeo SA, Warren RF, Wright TM
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