Publication date 2014 - Systematic Review
De Windt TS, Hendriks JAA, Zhao X, Vonk LA, Creemers LB, Dhert WJA, Randolph MA, Saris DBF

Concise Review: Unraveling Stem Cell Cocultures in Regenerative Medicine: Which Cell Interactions Steer Cartilage Regeneration and How?


Cartilage damage and osteoarthritis (OA) impose an important burden on society, leaving both young, active patients and older patients disabled and affecting quality of life. In particular, cartilage injury not only imparts acute loss of function but also predisposes to OA. The increase in knowledge of the consequences of these diseases and the exponential growth in research of regenerative medicine have given rise to different treatment types. Of these, cell-based treatments are increasingly applied because they have the potential to regenerate cartilage, treat symptoms, and ultimately prevent or delay OA. Although these approaches give promising results, they require a costly in vitro cell culture procedure. The answer may lie in single-stage procedures that, by using cell combinations, render in vitro expansion redundant. In the last two decades, cocultures of cartilage cells and a variety of (mesenchymal) stem cells have shown promising results as different studies report cartilage regeneration in vitro and in vivo. However, there is considerable debate regarding the mechanisms and cellular interactions that lead to chondrogenesis in these models. This review, which included 52 papers, provides a systematic overview of the data presented in the literature and tries to elucidate the mechanisms that lead to chondrogenesis in stem cell cocultures with cartilage cells. It could serve as a basis for research groups and clinicians aiming at designing and implementing combined cellular technologies for single-stage cartilage repair and treatment or prevention of OA.

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2021 - Clinical Study

A comparison between Polyurethane and Collagen Meniscal Scaffold for Partial Meniscal Defects: Similar positive clinical results at a mean of 10-Years of Follow-up.

Filardo G, Grassi A, Lucidi GA, Poggi A, Reale D, Zaffagnini S
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2003 - Basic Science

A porous polymer scaffold for meniscal lesion repair–a study in dogs.

Buma P, de Groot JH, Heijkants RG, Pennings AJ., Tienen TG, Veth RP
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