Publication date 2011 - Systematic Review
Pereira H, Frias AM, Oliveira JM., Espregueira-Mendes J, Reis RL

Tissue engineering and regenerative medicine strategies in meniscus lesions.

Partial meniscal substitution using acellular scaffolds in selected
patients with irreparable loss of tissue may be a safe and promising procedure.
However, there is only 1 randomized controlled study supporting its application,
and globally, many methodologic issues of published trials limit further
conclusions. We registered a different trend in preclinical trials, with most
considering augmentation of scaffolds by cells and/or GFs, as opposed to the
predominantly acellular approach in clinical trials. Different TERM approaches to
enhance meniscal repair or regeneration are in preclinical analysis, such as the
use of mesenchymal stem cells, gene therapy, and GFs alone or in combination, and
thus could be considered in the design of subsequent trials.

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2021 - Clinical Study

A comparison between Polyurethane and Collagen Meniscal Scaffold for Partial Meniscal Defects: Similar positive clinical results at a mean of 10-Years of Follow-up.

Filardo G, Grassi A, Lucidi GA, Poggi A, Reale D, Zaffagnini S
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2003 - Basic Science

A porous polymer scaffold for meniscal lesion repair–a study in dogs.

Buma P, de Groot JH, Heijkants RG, Pennings AJ., Tienen TG, Veth RP
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